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KMID : 1189420190320040062
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2019 Volume.32 No. 4 p.62 ~ p.89
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Comparison of the Effects of Topical Nasal Application on Allergic Rhinitis between Korean and Western Medicine : A Systematic Review of Randomized Controlled Trials
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Jo Hyo-Rim
Oh Se-Hee
Kim Seon-Hye
Sung Won-Suk
Hong Seung-Ug
Kim Eun-Jung
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Abstract
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Objectives : The purpose of this study is to evaluate the effectiveness and safety of topical nasal application of Herbal medicine compared with Western medicine in the treatment of Allergic Rhinitis(AR).
Methods : Electronic databases including Cochrane library, PubMed, EMBASE, CNKI, KMBASE, KISS, NDSL, OASIS, KISS and KJTK(Korean Traditional Knowledge Portal) were searched by the keywords such as ‘allergic rhinitis’, ‘nasal sprays’, ‘herbal medicine’, ‘plant extracts’, and ‘external application’. The quality of each RCTs was assessed by Cochrane Collaboration of ‘Risk of bias(RoB) Tool’.
Results : 19 RCTs were finally selected from 1419 references screened. 19 RCTs were compared with the effects of topical nasal application of Herbal medicine and Western medicine. Based on the symptom scores from 13 RCTs, topical nasal application of herbal medicine generally has a better effect on relief of AR. The two treatments have similar effects on improving the level of specific factors like IgE, IgG, IL-13, uLTD₄ in blood and urine. 8 RCTs showed adverse effects(AEs) in both groups and severe AEs were not reported.
Conclusions : This study shows that topical nasal application of herbal medicine can improve symptoms and related factors of allergic rhinitis. Well-designed RCT studies with low risk of bias should be conducted to confirm these findings.
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KEYWORD
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Allergic Rhinitis, Herbal Medicine, Nasal Application, Randomized Controlled Trial(RCT)
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